Edition V08N02 | Year 2014 | Editorial Expedientelicações e Aplicações | Pages 10 to 19
The use of bisphosphonates induces clinicians to fear and care. hese reactions are associated with controversy resulting from lack of deep knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. here is no scientiic evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and maxillary osteomyelitis. heir use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or experiment trials with failing methods. Additional studies will always be necessary. However, deep knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications.