Edition V06N02 | Year 2012 | Editorial Pergunte a um Expert | Pages 29 to 34
What is the origin of BMPs and how extensive is the synonymy employed to identify them?
The morphogenetic proteins of the bone are responsible for signaling to induce bone formation. BMPs (bone morphogenetic proteins) represent a family with more than 20 reported proteins, which are part of the transforming growth ß factor family (TGF-ß), activating and inhibiting the differentiation and growth factors (GDF). They are involved in embryonic development and in the formation of the skeleton. Since the work of Urist3 in 1965, demonstrating that the demineralized bone matrix could induce the formation of cartilage and bone in ectopic sites, many researchers have endeavored to clarify the activity of matrix components.