Bisphosphonates-related osteonecrosis of the jaws

Admin Dental Press

Edition V09N03 | Year 2015 | Editorial Artigo Inédito | Pages 101 to 109

Joao Ferreira Dos Santos, Bruno Feital Fusaro, Antonio Carlos Costa Bento Júnior, Leonardo Coelho Lima Salgado, Andressa Antunes Prado De França

Introduction: osteonecrosis of the jaws associated with the use of bisphosphonates has been a relevant subject matter addressed by dental clinics in the current century. The medication has been widely used and, for this reason, dental surgeons have faced the need to deepen their knowledge on such a theme, particularly because necrotic lesions associated with the use of bisphosphonates negatively affect patients’ quality of life while also lead to their significant morbidity. Thus, knowing about the disease, its epidemiology, as well as risk rates and patients’ management has been rendered necessary. Objective: the present study’s general aim was to search the literature for relevant information on the pathology and medication by means of a literature review. Methods: an electronic search was conducted in EBSCO and MEDLINE databases for articles published between 1996 and 2014. Original articles and literature reviews providing the grounds for the development of the subject matter of choice were selected. Results: a total of 22 articles met the established criteria. While the research was being conducted, other medications associated with the disease were also found. Those medications are reported in this study as well. Conclusions: as a result of bisphosphonates use, bone tissue has its resorption capacity decreased, thus increasing the potential for lack of healing and consequent necrosis. Additionally, the action exerted by the medications is evinced, as they inhibit soft tissue cells and blood vessels proliferation. Finally, the importance of adequate patient management regarding the use of drugs for subjecting patients to surgical procedures is shown.

Osteonecrosis, Osteoclasts, Bone,

Santos JF, Fusaro BF, Bento Júnior, ACC, Salgado LCL, França AAP. Bisphosphonates-related osteonecrosis of the jaws. Dental Press Implantol. 2015 July-Sept;9(3):101-9. DOI:

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